Endocrine Abstracts

Cushing’s syndrome caused by ectopic ACTH secretion (EAS) constitutes ~10% of Cushing’s syndrome (CS).The aim of this study was to present experience of our Clinic with EAS.).Patients: Twelve patients, aged 14–70 years: four females and eight males.Outcomes and measurements: Clinical features, medical examination, morning electrolytes, glucose level, serum cortisol, ACTH levels, midnight plasma...

Background: Double pituitary adenomas are a rare entity, which requires clinical attention and a careful follow-up.Case report: A 37-year-old man presented with left-sided painful gynecomastia. He denied typical symptoms of excessive growth hormone (GH) secretion and did not show any acromegalic features. Due to low testosterone and LH levels with mild hyperprolactinaemia, the patient was referred to pituitary MR, which revealed an 11 × 13 mm right-...

Introduction: Combined pituitary hormone deficiency (CPHD) due to PROP1 mutation is a rare cause of childhood-onset pituitary disfunction. Treatment with growth hormone is crucial for the proper development during childhood and adolescence, and to maintain adequate metabolic processes in the adulthood. There are other factors influencing patients metabolism e.g. steroid and estradiol/testosterone treatment.Aim: To assess metabolic status of patients with...

Background: Patients with acromegaly have substantially reduced quality of life (QoL). Delayed diagnosis is common and a long duration of untreated acromegaly leads to decreased QoL and increased morbidity and mortality.Aim: This longitudinal study examined QoL in patients with acromegaly who received lanreotide autogel.Material and Methods: This was a 2-year prospective, observational, multicenter study conducted in Poland (NCT023...

Introduction: The autoimmune process is currently the most common cause ofthe primary adrenal insufficiency cases in developed countries. The complexity of this process consists of genetic, immunological and environmental factors. It has been proven that vitamin D (VD) inhibits the production of inflammatory cytokines and can modulate immune-regulatory mechanisms.Purpose: The aim of our study was to evaluate the prevalence of VD insufficiencyin...

Introduction: The aim of this study was to assess the efficacy of peptide receptor radionuclide therapy (PRRT) with the use of 90Y-DOTATATE and the survival rate of patients with disseminated or non-operable neuroendocrine tumors (NETs).Methods: In the time period from June 2006 to October 2012, 70 patients were treated with PRRT in our department. The 90Y-DOTATATE therapeutic activity was calculated per total body surface area up t...

Introduction: In accordance with a rising number of pregnant women with thyroid gland dysfunctions, The Thyroid Gland’s Disorders Outpatient Clinic for Pregnant Women has started its activity in our Endocrinology Department in January 2008. Patients with or without thyroid gland dysfunction in history have been under medical care.During pregnancy thyroid gland is prone to the number of physiological changes, which cause difficulties in the interpret...

Thyroid disease let to change of weight – in hyperthyroid body mass is reduced, but in hypothyroid it is increased. Recently researches suggest that many new bioactive substances, like ghrelin and obestatin, play a role in regulation of body mass. These closely related hormones have paradoxically different effects- ghrelin increases, but obestatin decreases appetite. The aim of the study was to evaluate ghrelin and obestatin levels in young patients with untreated Graves&...

The incidence of gastric neuroendocrine tumors (GNT) is increasing, what can be explained by the increased detection caused by the common use of the endoscopy and the pervasive use of acid suppressive therapy leading to enterochromatofine like cells proliferation. There are numerous new diagnostic/therapeutic GNT methods in use like: EUS, SRS, somatostatin therapy and 90Y/177Lu-DOTA-TATE radiotherapy.Materials and methods: In 1998–2008 37 patients w...

Background: Multiple endocrine neoplasia syndrome type 2 (MEN2) is a rare disease characterised by inherence in each patient medullary thyroid carcinoma (MTC), pheochromocytoma and in type MEN 2a primary hyperparathyroidism, in type MEN2b marfanoid habitus and neurofibromas. Mutation in RET proto-oncogene at chromosome 10 is a molecular cause of MEN2 syndrome.Methods: Eighteeen patients with MEN2 syndrome were enrolled: (10 women and 8 men) mean age 22&#...